Scientific advance delves deeper into cancer than ever before

Researchers can now read the genomes of single cells within a tumour

Dr. Samuel Aparicio, BC Cancer distinguished scientist and co-lead author on the study. Photo by BC Cancer Foundation.

Dr. Samuel Aparicio, BC Cancer distinguished scientist and co-lead author on the study. Photo by BC Cancer Foundation.

Republished with permission from the BC Cancer Foundation

VANCOUVER, B.C. – BC Cancer scientists, in partnership with the University of British Columbia, Memorial Sloan Kettering Cancer Center (MSK) and Microsoft have developed a new method for analyzing cancer tissue, allowing them to learn more about cancer than previously possible. Researchers can now read the genomes of single cells within a tumour, opening up a new wave of understanding of how and why cancer develops and changes over time.

This new method is so sensitive that researchers will now be able to analyze single cells from a tissue, and decode their genomes individually. This is a key element to understanding cell evolution – including how normal, seemingly healthy cells become cancerous and why cancerous cells spread and become resistant to treatment over time. The method will unlock the answers to crucial questions like: the origins of cancer, why cancers evolve, why they become resistant to drugs and why they metastasize. This research will also be a key pathway to cancer prevention, understanding the root environmental causes of the disease.

“The ways in which the cells differ from each other turns out to be important for understanding why they stop responding to treatments,” says Dr. Samuel Aparicio, BC Cancer distinguished scientist and co-lead author on the study with Dr. Sohrab Shah, BC Cancer scientist and current chief of computational oncology at Memorial Sloan Kettering. “It also tells us something about the history of the cancer; how it developed, how long it’s been inside healthy tissue, and how long it’s been growing. In some cases, a pattern of mutation in the genome might tell us that that person has been exposed to a carcinogen or some other thing in the environment which predisposes to that cancer. That’s what the methodology brings – the ability to address all of those questions.”

The new approach brings together leading-edge methods in genomics and computer science from the laboratories of Dr. Aparicio and Dr. Shah.

This advance comes nearly a decade after Dr. Aparicio and Dr. Shah and their team’s first foundational shift in decoding cancer: the ability to sequence human cancer genomes, which opened up a new era in understanding cancer and has since been transformational in the field.

The team began with two genomes, in a 2009 landmark study of cancer metastasis in a breast cancer and today has decoded more than 500,000 single cell cancer genomes, 50,000 of which are released into the public domain through this study. In the last ten years, cancer genomics findings have sparked new drug treatments, new ways of diagnosing cancer and new ways of monitoring cancer.

“Basic and translational research is essential to advancing medical discoveries that will have a profound impact on patient care,” says Dr. François Bénard, vice president, research, BC Cancer. “We are proud of the work our researchers do and the collaboration between partners including the University of British Columbia and Memorial Sloan Kettering.”

“A new era of breakthrough cancer research and treatment is here, thanks in large part to our donors who have supported Dr. Aparicio and his team at BC Cancer for the past decade, bringing hope and promise to patients in B.C.,” says Sarah Roth, president & CEO, BC Cancer Foundation.

“Sometimes obtaining the knowledge takes a bit of time and persistence, but there’s a message of hope in here,” says Dr. Aparicio. “Over the next ten years, we anticipate this technology will enable a fundamentally improved understanding of cancer biology leading to better ways to target cancers, predict response to therapy and combine interventions to improve the lives of patients.”

“We’re excited to be able to present this technology to other scientists, both at MSK and beyond,” adds Dr. Shah.

Research teams in the United Kingdom and United States have already begun to adopt the methodology developed at BC Cancer in Vancouver.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Photo collage of loved ones lost to substance use and overdose. (Photo courtesy Moms Stop The Harm)
B.C. overdose deaths still rising 5 years after public health emergency declared

Moms Stop the Harm calls on B.C. to provide safe supply in response to deadly illicit drug use

Angelique Houlihan gets her COVID-19 vaccine jab last week at the community-wide clinic. (Angelique Houlihan photo)
Vaccine clinic continues this week

Plenty of booking spots available

District of Houston
Council adds flexibility to spending decisions

Singles out road works as potential beneficiary

Filling potholes in Houston
Holes filled on Highway 16

Potholes aren’t restricted to District of Houston streets. Lakes District Maintenance crews… Continue reading

In the past, the pitch-in days saw the community working together to clean-up unlike this year, when they will be encouraged to stay in their own bubbles. (Shiela Pepping photo/Houston Today)
Houston to pitch-in on Apr. 22

The Houston & District Chamber of Commerce’s 60th pitch-in day

Demonstrators at the legislature on April 14 called on the province to decriminalize drug possession and provide widespread access to regulated safe supply across B.C. (Jake Romphf/News Staff)
Rally calls for decriminalization, safe supply on 5th anniversary of overdose emergency declaration

From 2016 to the end of February, 7,072 British Columbians died due to overdose

(Government of Canada)
Liberal MP caught stark naked during House of Commons video conference

William Amos, in Quebec, appeared on the screens of his fellow members of Parliament completely naked

Provincial health officer Dr. Bonnie Henry updates B.C.’s COVID-19 situation at the B.C. legislature, Feb. 1, 2020. (B.C. government)
B.C.’s COVID-19 case count jumps to 1,168 Wednesday, nearly 400 in hospital

Now 120 coronavirus patients in intensive care, six more deaths

Moss covered branches are seen in the Avatar Old Growth Forest near Port Renfrew on Vancouver Island, B.C. Thursday, Sept. 29, 2011. THE CANADIAN PRESS/Jonathan Hayward
B.C. blockades aimed at protecting old-growth forests reveal First Nation split

Two Pacheedaht chiefs say they’re ‘concerned about the increasing polarization over forestry activities’ in the territory

Richmond RCMP Chief Superintendent Will Ng said, in March, the force received a stand-out number of seven reports of incidents that appeared to have “racial undertones.” (Phil McLachlan/Capital News)
‘Racially motivated’ incidents on the rise in B.C’s 4th largest city: police

Three incidents in Richmond are currently being invested as hate crimes, says RCMP Chief Superintendent Will Ng

Commercial trucks head south towards the Pacific Highway border crossing Wednesday (April 14, 2021). The union representing Canadian border officers wants its members to be included on the frontline priority list for the COVID-19 vaccine. (Aaron Hinks photo)
CBSA officers’ union calls for vaccine priority in B.C.

Border officers at ports including, YVR and land crossings should ‘not be left behind’

A still from the video taken of a violent arrest on May 30, 2020 in downtown Kelowna. (File)
Kelowna Mountie charged with assault for caught-on-camera violent arrest

Const. Siggy Pietrzak was filmed punching a suspected impaired driver at least 10 times during an arrest

A screenshot from a Nuu-chah-nulth healing song and performance created in collaboration between Hjalmer Wenstob and Timmy Masso. (Screenshot from YouTube)
VIDEO: Tla-o-qui-aht First Nation brothers produce COVID-19 healing song

Hjalmer Wenstob and Timmy Masso share dance and inspiration.

Most Read