Lonesome George was the famed last representative of a giant tortoise species once found on the Galapagos island of Pinta. Image credit: Mark Putney

Famous giant tortoise DNA may hold fountain of youth: UCBO

After Lonesome George’s death he still provides clues to longer life

Ever since Darwin’s first steps on the Galapagos Islands, understanding the adaptations that offer the giant tortoise its extended lifespan has been a tantalizing scientific pursuit.

And now, new research by an international team including researchers from UBC’s Okanagan campus has used the DNA from one famous giant tortoise to uncover the genes that are associated with their longevity. The discovery provides clues to better understand aging in humans and may help preserve the species says Michael Russello, study co-author and biology professor at UBC Okanagan.

“Giant tortoises are among the longest living vertebrate animals and have become an interesting model for studying longevity and age related-disease,” said Russello. “Even though they’re one of few animals that can live longer than 100 years, there has been surprisingly little research into the giant tortoise genome.”

RELATED: UBCO and BCIT team up to brew cannabis-infused beverages

To help identify the genes that give the giant tortoise its extended lifespan, the researchers compared the complete DNA sequence from two long-lived giant tortoises. They used samples from Lonesome George—the famed last representative of a species once found on the Galapagos island of Pinta—and from another giant tortoise species found on the Aldabra atoll, a coral island in the Indian Ocean.

RELATED: UBCO sociology class calls on Kelowna Chiefs to change “derogatory” name

By comparing the giant tortoise genomes with those from other species, including humans, they found interesting variation within genes linked to DNA repair, immune response, and cancer suppression not possessed by shorter-lived vertebrates. None of those genomic variants had been previously associated with aging, offering new avenues for further study.

While individual tortoises have remarkable longevity, Russello says the Galapagos giant tortoises do not, with all living species considered threatened or endangered. He says the results of their study could provide clues into the biological processes and adaptations that gave rise to giant tortoises in the first place, while helping to better protect these animals on the verge of disappearing altogether.

“Lonesome George was a very interesting character in his own right, embodying the plight of endangered species until his death in 2012,” said Russello. “While he inspired many while he was alive, his legacy now lives on through a story written in his DNA.”

To report a typo, email:
newstips@kelownacapnews.com
.


@KelownaCapNews
newstips@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

COVID-19 cases grow to 13 at B.C. First Nation near Fort St. James

“This is very serious,” says Nak’azdli Whut’en Chief

Cullen confirmed as B.C. NDP candidate for Stikine despite party’s equity policy

Former Tahltan Central Government President Annita McPhee said the process made her feel “abused”

Citing stability, B.C. Premier calls snap election for Oct. 24

John Horgan meets with Lieutenant Governor to request vote

Routine medical check for adult canadians; what you need to know

Preventive Medicine is a proactive method of health care delivery. Its’ aim… Continue reading

B.C. records 98 more COVID-19 cases, most in Lower Mainland

One new senior home outbreak, Surrey Memorial outbreak over

PHOTOS: 2nd calf in a month confirmed among Southern Resident killer whale pod

Center for Whale Research said they will eagerly await to observe the calf to evaluate its health

2 British Columbians arrested, 3 at large in massive Alberta drug bust

Eight people are facing 33 charges in what police have dubbed Project Incumbent

97 distressed horses, cats and dogs seized from farm in Princeton

RCMP assisted as BC SPCA executed search warrant

$250K reward offered as investigation continues into Sea to Sky Gondola vandalism

Police also asking for specific footage of Sea to Sky highway around time of incident

Join Black Press Media and Do Some Good

Pay it Forward program supports local businesses in their community giving

Trudeau ‘disappointed’ by RCMP treatment of Sikh officers over mask issue

World Sikh Organization of Canada said taking Sikh officers off the front lines constitutes discrimination

Liberals reach deal with NDP on COVID-19 aid bill, likely averting election

NDP and the Liberals have reached an agreement on COVID-19 sick-leave

Money laundering inquiry delayed over of B.C. election: commissioner

Austin Cullen says the hearings will start again on Oct. 26

Most Read